Dante Labs, a business with offices in Europe and U . s . States, have partnered with numerous laboratories worldwide and therefore are now using next-gen sequencing technology to map a person’s complete genome—all three-billion base pairs—in around 8 days, as well as for under €1,000 ($1,175). This particular service is comparable to the now fairly ubiquitous whole exome sequencing broadly marketed by 23andMe yet others, which Medgadget also reviewed lately. The Whole Genome Sequencing (WGS) provided by Dante Labs is much more comprehensive, however: it codes over 99% from the genome when compared with around 1% for that exome tests.
Dante Labs’ Whole Genome Sequencing service in Europe presently retails for €850 ($1,000), with discounts on certain marketing days, including Amazon . com prime days, because of a current partnership. An additional benefit for data-enthusiasts available (myself incorporated) would be that the WGS service provides the chance for that user to get a text-file copy from the full genome along with the summary report. Additionally to WGS, Dante Labs offer numerous more limited risk-targeted tests for between €300 ($350) and €500 ($600).
Another major advantage of really finding the WGS raw data in the original analysis is the opportunity to consult the growing quantity of third-party genome analysis providers. The Dante Labs team were very useful in pointing me towards two platforms particularly – sequencing.com and promethease.com – where lots of further disease risk, drug-resistance, family tree, or appearance decoding can be achieved with apps and reports.
The sample collection vial prior to being full of saliva and came back straight to Dante Labs
My WGS package showed up within 72 hours of placing an order. The wallet-sized box contained the DNA sampling package, instructions, and details on how you can return my sample to Dante Labs. Getting filled the little vial with my saliva (taking around fifteen minutes of spitting and oral cavity massaging) the sample was combined with a buffer solution once the vial was sealed, and everything was ready for shipping. I dropped the package off in a local DHL point, and a few days later I had been notified that my sample have been received through the Dante Labs team in Italia to start sequencing.
Then, I anxiously waited.
This appears like a good thing to mirror on Dante Labs’ slogan “Never Worry Again” and think about basically had just put myself with any type of ethical or privacy conundrum. In the end, sequencing my genome could elucidate a increased chance of fatal or costly-to-treat illnesses, reveal a carrier status of rare genetic conditions, evaluate drug resistance, and usually give anybody having a copy from the result probably the most detailed insight possible into how my body system works.
First, I believe the privacy real question is simpler to deal with. Payment for that services are by Paypal or debit/charge card, and also the sample package will be sent to a previous address. Any name, email and address will be connected by having an 8-digit sample number behind Dante Labs’ encrypted system this sample number is exactly what seems on all subsequent correspondence as well as in the ultimate report. Dante Labs are compliant with relevant U.S. HIPAA rules, the EU Data Protection Directive program, and also the EU-US Privacy Shield.
The moral real question is harder. Will I actually want to know everything of my genome? Once I know it, must i ever disclose it? Therefore, whom must i tell? Do I wish to determine if I’ve a heightened chance of Alzheimer’s, cancer, or sudden dying syndrome? And really should I be covering everything on the web? Together with things i suspect is most people, I’m still within the “I don’t figure out what I think” camp on these questions, and particularly regarding knowing risks that could be shared within families. Hence, with this along with other reasons, within the discussion below I’ve overlooked any improvements associated with clinical significance.
The End Result
Almost eight days to the next day I came back my saliva sample an e-mail made an appearance within my inbox notifying me the analysis was complete. Connected to the email evolved as the result: a 160-page Wellness and Durability Report along with a 951MB text file that contained my entire genome. A sobering thought.
The very first factor to indicate here’s that, unsurprisingly, a genome is a great deal of information to become coping with. The summary report initially glance made an appearance mind-bogglingly detailed. Numerous SNPs (Single Nucleotide Polymorphisms) are listed with symbol of both my allele and also the traits connected with various alleles.
I’m led with the report by instructions that inform me from the distinction between genes connected with growing the chance of conditions versus individuals that are recognized to cause conditions. There’s also indicators of risk, severity, clinical significance, and actionability where suitable for each finding. Finally, detailed summaries of every gene reported indicate the amount of studies conducted and also the corresponding citations. It’s also worth noting the report results are only able to use current research findings, which might change later on with increased or better studies. An excellent resource that aggregates all current findings for particular SNPs is SNPedia.
So, what did I learn?
My genome report properly identified me as male. Check. I’m also “Generally European” and have the gs241 variant that’s associated with eco-friendly, light-brown, or hazel eyes. Again, all very in line with my appearance. I don’t taste phenylthiocarbamide and other alike food compounds as bitter, and therefore I ought to benefit from the taste of raw vegetables like broccoli and cabbage in addition to draft beer. Check, again.
The encoding on my small CYP1A2 gene suggests that i’m within the minority of people in getting the allele connected with metabolizing caffeine faster, and therefore it’s less impact on me. This seems to be real from anecdotal strong coffee consuming. I just read afterwards which i also hold the genotype connected with craving alcohol many metabolizing it faster, which might indicate me as being a good consuming companion in your next evening out.
Happily, I’ve got a reduced chance of hair loss, that has born-out as true to date within my existence and could be in conjuction with the other men within my family. I do indeed tan instead of freckle or sunburn because the AA alleles of rs1015362 on my small 20th chromosome would attest. My CT alleles on rs17822931 properly claim that my earwax is wet, and i’m very happy to read that being heterozygous on a single SNP can also be connected with “slightly better body odor.” I flatter myself to consider that—yes—I am much more of a sprinter than the usual lengthy distance runner as tricked through the CC genotype of rs1815739 within my ACTN3 gene, although I’m suspicious that my short legs will also be an issue.
There’s also findings for more than 100 medications indicating should i be genetically predisposed not to react to a medicine, need a dose appropriate in my metabolic process, or would see particularly good results with every drug. Here I can tell real clinical significance and, should i be honest, this is actually the information I’d be probably to think about disclosing to some doctor.
Finally, there’s the data prone to awaken the hypochondriac habits throughout us—that linked in research to perils of various cancers, diabetes, cardiovascular disease, Alzheimer’s, as well as depression. This really is a part of the genetic profile that seems probably the most fraught with contradictory or potentially minor findings. That isn’t to state the test or report are problematic, but instead that there’s clearly simply not enough good proof of clinical outcomes associated with genetic expression, both individually as well as in concert. The potential risks alllow for interesting if slightly frightening studying and do seem to broadly support disease prevalence in a variety of generations of my loved ones, such illnesses are, however, not unusual and connected with senior years.
In studying the I discovered it was vital to become conscious from the complexity from the genome’s effects and also the relative infancy of great importance and from the research surrounding this. For example, I possess gene variants connected with an elevated and decreased chance of Alzheimer’s, according to current research. There are a variety more obvious-cut aspects towards the sequencing, for example drug interactions and carrier status of genetic illnesses, that we think do give genuine reassurance.
The greater light-hearted traits around food preferences and lifestyle quirks do have the symptoms of impressive precision. And i’m certain as research linking genetic variations with disease prevalence matures you’ll be able to attract ever-clearer clinical conclusions from my genome, for much better or worse. Possibly the primary lesson I learned in the whole process didn’t really require a full genome sequencing: I ought to eat better and workout more, with the hope of, as the suggests “outsmarting my genes and living an extended, more vibrant existence.”
Personally, i believe that the sheer scientific marvel of getting your full genome sequenced—a procedure barely possible and costing billions only twenty years ago—for the cost of the decent TV is a great enough reason alone to do this!
Note: Dante Labs conducted this genome sequencing totally free in return for an impartial review from Medgadget.
Link: Dante Labs…